| 1882 City Council of Charleston approves City Hospital to establish a nurse training school |
| 1883 Training school opens as a diploma program named the South Carolina Training School for Nurses |
| 1886 Catastrophic earthquake hits Charleston, resulting in the closure of Roper Hospital |
| 1895 School is reestablished as The Charleston Training School, a two-year diploma program |
| 1897 Hospital and Training School for Nurses established for the education of African-American nurses at 135 Cannon Street (later the McClennan-Banks Hospital) |
| 1904 Roper Hospital assumes administration of the nursing program and the name changes to Roper Hospital Training School for Nurses |
| 1919 Roper Hospital Training School for Nurses is incorporated with the Medical College becoming the School of Nursing of the Medical College of the State of South Carolina |
| 1919 The program is expanded to a three-year diploma program |
| 1924 Marguerite Andell becomes first director |
| 1948 Ruth Chamberlin becomes director |
| 1952 Ruth Chamberlin becomes the school’s first dean |
| 1953 School name is changed to School of Nursing of the Medical College of South Carolina and Roper Hospital |
| 1955 School name is changed again to School of Nursing of the Medical College of South Carolina |
| 1956 School of Nursing building constructed |
| 1965 H. Elizabeth Mills, Dean |
| 1969 Dr. Marcia Curtis, Dean |
| 1969 School of Nursing converts the three-year diploma program to a four-year Baccalaureate of Science in Nursing (BSN) program |
| 1970 School receives its current name, College of Nursing of the Medical University of South Carolina |
| 1979 College of Nursing opens a Master of Science in Nursing (MSN) program |
| 1986 Dr. Sharon Hoffman, Dean |
| 1995 Dr. Maureen Keefe, Dean |
| 2001 College of Nursing opens a Doctor of Philosophy (PhD) in Nursing program |
| 2002 Dr. Gail W. Stuart, Dean |
| 2009 College of Nursing opens a Doctor of Nursing Practice (DNP) program |
| 2014 Renovation and rededication of College of Nursing building |